There are two connotations to this question.
One, helplessness. “What can I do?” Deciding outright that you have no power to change anything, and thus, succumbing to victim mode.
Two, responsibility. “What can I do?” You understand things have not been working as expected, and you are curious to help. You know that sometimes one step of help and understanding towards positive change is more than enough.
You can do a lot. Or you cannot. The best thing is you are the one who decides, regardless of what is happening.